GNSS reflectometry for land remote sensing applications

Soil moisture and vegetation biomass are two essential parameters from a scienti c and economical point of view. On one hand, they are key for the understanding of the hydrological and carbon cycle. On the other hand, soil moisture is essential for agricultural applications and water management, and vegetation biomass is crucial for regional development programs. Several remote sensing techniques have been used to measure these two parameters. However, retrieving soil moisture and vegetation biomass with the required accuracy, and the appropriate spatial and temporal resolutions still remains a major challenge. The use of Global Navigation Satellite Systems (GNSS) reflected signals as sources of opportunity for measuring soil moisture and vegetation biomass is assessed in this PhD Thesis. This technique, commonly known as GNSS-Reflectometry (GNSS-R), has gained increasing interest among the scienti c community during the last two decades due to its unique characteristics. Previous experimental works have already shown the capabilities of GNSS-R to sense small reflectivity changes on the surface. The use of the co- and cross-polarized reflected signals was also proposed to mitigate nuisance parameters, such as soil surface roughness, in the determination of soil moisture. However, experimental evidence of the suitability of that technique could not be demonstrated. This work analyses from a theoretical and an experimental point of view the capabilities of polarimetric observations of GNSS reflected signals for monitoring soil moisture and vegetation biomass. The Thesis is structured in four main parts. The fi rst part examines the fundamental aspects of the technique and provides a detailed review of the GNSS-R state of the art for soil moisture and vegetation monitoring. The second part deals with the scattering models from land surfaces. A comprehensive description of the formation of scattered signals from rough surfaces is provided. Simulations with current state of the art models for bare and vegetated soils were performed in order to analyze the scattering components of GNSS reflected signals. A simpli ed scattering model was also developed in order to relate in a straightforward way experimental measurements to soil bio-geophysical parameters. The third part reviews the experimental work performed within this research. The development of a GNSS-R instrument for land applications is described, together with the three experimental campaigns carried out in the frame of this PhD Thesis. The analysis of the GNSS-R and ground truth data is also discussed within this part. As predicted by models, it was observed that GNSS scattered signals from natural surfaces are a combination of a coherent and an incoherent scattering components. A data analysis technique was proposed to separate both scattering contributions. The use of polarimetric observations for the determination of soil moisture was demonstrated to be useful under most soil conditions. It was also observed that forests with high levels of biomass could be observed with GNSS reflected signals. The fourth and last part of the Thesis provides an analysis of the technology perspectives. A GNSS-R End-to-End simulator was used to determine the capabilities of the technique to observe di erent soil reflectivity conditions from a low Earth orbiting satellite. It was determined that high accuracy in the estimation of reflectivity could be achieved within reasonable on-ground resolution, as the coherent scattering component is expected to be the predominant one in a spaceborne scenario. The results obtained in this PhD Thesis show the promising potential of GNSS-R measurements for land remote sensing applications, which could represent an excellent complementary observation for a wide range of Earth Observation missions such as SMOS, SMAP, and the recently approved ESA Earth Explorer Mission Biomass.La humedad del suelo y la biomasa de la vegetaci on son dos parametros clave desde un punto de vista tanto cient co como econ omico. Por una parte son esenciales para el estudio del ciclo del agua y del carbono. Por otra parte, la humedad del suelo es esencial para la gesti on de las cosechas y los recursos h dricos, mientras que la biomasa es un par ametro fundamental para ciertos programas de desarrollo. Varias formas de teledetección se han utilizado para la observaci on remota de estos par ametros, sin embargo, su monitorizaci on con la precisi on y resoluci on necesarias es todav a un importante reto tecnol ogico. Esta Tesis evalua la capacidad de medir humedad del suelo y biomasa de la vegetaci on con señales de Sistemas Satelitales de Posicionamiento Global (GNSS, en sus siglas en ingl es) reflejadas sobre la Tierra. La t ecnica se conoce como Reflectometr í a GNSS (GNSS-R), la cual ha ganado un creciente inter es dentro de la comunidad científ ca durante las dos ultimas d ecadas. Experimentos previos a este trabajo ya demostraron la capacidad de observar cambios en la reflectividad del terreno con GNSS-R. El uso de la componente copolar y contrapolar de la señal reflejada fue propuesto para independizar la medida de humedad del suelo de otros par ametros como la rugosidad del terreno. Sin embargo, no se pudo demostrar una evidencia experimental de la viabilidad de la t ecnica. En este trabajo se analiza desde un punto de vista te orico y experimental el uso de la informaci on polarim etrica de la señales GNSS reflejadas sobre el suelo para la determinaci on de humedad y biomasa de la vegetaci on. La Tesis se estructura en cuatro partes principales. En la primera parte se eval uan los aspectos fundamentales de la t ecnica y se da una revisi on detallada del estado del arte para la observaci on de humedad y vegetaci on. En la segunda parte se discuten los modelos de dispersi on electromagn etica sobre el suelo. Simulaciones con estos modelos fueron realizadas para analizar las componentes coherente e incoherente de la dispersi on de la señal reflejada sobre distintos tipos de terreno. Durante este trabajo se desarroll o un modelo de reflexi on simpli cado para poder relacionar de forma directa las observaciones con los par ametros geof sicos del suelo. La tercera parte describe las campañas experimentales realizadas durante este trabajo y discute el an alisis y la comparaci on de los datos GNSS-R con las mediciones in-situ. Como se predice por los modelos, se comprob o experimentalmente que la señal reflejada est a formada por una componente coherente y otra incoherente. Una t ecnica de an alisis de datos se propuso para la separacióon de estas dos contribuciones. Con los datos de las campañas experimentales se demonstr o el bene cio del uso de la informaci on polarim etrica en las señales GNSS reflejadas para la medici on de humedad del suelo, para la mayor a de las condiciones de rugosidad observadas. Tambi en se demostr o la capacidad de este tipo de observaciones para medir zonas boscosas densamente pobladas. La cuarta parte de la tesis analiza la capacidad de la t ecnica para observar cambios en la reflectividad del suelo desde un sat elite en orbita baja. Los resultados obtenidos muestran que la reflectividad del terreno podr a medirse con gran precisi on ya que la componente coherente del scattering ser a la predominante en ese tipo de escenarios. En este trabajo de doctorado se muestran la potencialidades de la t ecnica GNSS-R para observar remotamente par ametros del suelo tan importantes como la humedad del suelo y la biomasa de la vegetaci on. Este tipo de medidas pueden complementar un amplio rango de misiones de observaci on de la Tierra como SMOS, SMAP, y Biomass, esta ultima recientemente aprobada para la siguiente misi on Earth Explorer de la ESA

Diseño de un portal web de una red social para aficionados al deporte

[ES] El objetivo del trabajo consiste en realizar el diseño de un portal web de una red social para aficionados al deporte, en este caso será para aficionados al futbol sala. Esta red social permitirá a los aficionados al fútbol sala poder comunicarse con los distintos usuarios. Entre las distintas funciones los usuarios podrán realizar peticiones de amistad, subir sus propias imágenes, realizar publicaciones y enviar mensajes privados entre los usuarios. Además, podrán crear partidos siendo los administradores del mismo y unirse a partidos de otros usuarios[EN] The main purpose of this work is to design a social network website for sports fans, particularly it will be for futsal fans. This social network will allow futsal fans to communicate easily with other members. Among the different functions that users have on the website, they will be able to send friendship requests, upload their own pictures, make some publications and send private messages to other people. In addition, they can set matches, administrate and manage them and join different games or events.Martínez Egido, A. (2017). Diseño de un portal web de una red social para aficionados al deporte. http://hdl.handle.net/10251/88941.TFG

Tenofovir Nephrotoxicity: 2011 Update

Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondria-rich cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial. Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity. Newer, structurally similar molecular derivatives that do not accumulate in proximal tubules are under study

LOTUS— Preparing Sentinel-3 Ocean and Land SAR Altimetry Processing for Copernicus

The Sentinel-3 satellite mission with its SRAL instrumentation contains new features compared to the conventional radar altimeter mission that form the basis for new innovative GMES products and applications that are not considered or implemented in the Copernicus services yet. To utilize the full potential of the new data source, new methods and processing chains need to be developed. Also, new potential Copernicus products should be developed that utilize the improved along-track resolution over both the oceans and over land. Then new operational processing, validation and delivery mechanisms need to be developed and implemented for generating the new dynamic products. A smooth transition from old to new products is important to ensure existing services. Finally, the take-up of the new Copernicus products by the value-adding sectors needs to be stimulated and demonstrated to ensure that they will be used for commercial activities. The main objectives of the LOTUS project is to prepare the take-up of data from Sentinels 3. In the initial phase, LOTUS will develop processing scheme for extracting high-resolution sea surface heights, wave heights and wind speeds from SAR mode data. Over land, the LOTUS will develop processing scheme for extracting high-resolution river and lake heights, soil moisture, and snow water equivalents. This presentation show some preliminary results based on analyses using CRYOSAT data. Furthermore, new DEMO data sets are presented. These data sets facilitate the development of marine and hydrological services for Copernicus and the down-stream segment

Design and rationale of a multicentre, randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of vitamin D on ventricular remodelling in patients with anterior myocardial infarction: the VITamin D in Acute Myocardial Infarction (VITDAMI) trial

Introduction:Decreased plasma vitamin D (VD) levels are linked to cardiovascular damage. However, clinical trials have not demonstrated a benefit of VD supplements on left ventricular (LV) remodelling. Anterior ST-elevation acute myocardial infarction (STEMI) is the best human model to study the effect of treatments on LV remodelling. We present a proof-of-concept study that aims to investigate whether VD improves LV remodelling in patients with anterior STEMI. Methods and analysis:The VITamin D in Acute Myocardial Infarction (VITDAMI) trial is a multicentre, randomised, double-blind, placebo-controlled trial. 144 patients with anterior STEMI will be assigned to receive calcifediol 0.266 mg capsules (Hidroferol SGC)/15 days or placebo on a 2:1 basis during 12 months. Primary objective:to evaluate the effect of calcifediol on LV remodelling defined as an increase in LV end-diastolic volume >= 10\% (MRI). Secondary objectives:change in LV end-diastolic and end-systolic volumes, ejection fraction, LV mass, diastolic function, sphericity index and size of fibrotic area; endothelial function; plasma levels of aminoterminal fragment of B-type natriuretic peptide, galectin-3 and monocyte chemoattractant protein-1; levels of calcidiol (VD metabolite) and other components of mineral metabolism (fibroblast growth factor-23 (FGF-23), the soluble form of its receptor klotho, parathormone and phosphate). Differences in the effect of VD will be investigated according to the plasma levels of FGF-23 and klotho. Treatment safety and tolerability will be assessed. This is the first study to evaluate the effect of VD on cardiac remodelling in patients with STEMI. Ethics and dissemination: This trial has been approved by the corresponding Institutional Review Board (IRB) and National Competent Authority (Agencia Espanola de Medicamentos y Productos Sanitarios (AEMPS)). It will be conducted in accordance with good clinical practice (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use-Good Clinical Practice (ICH-GCP)) requirements, ethical principles of the Declaration of Helsinki and national laws. The results will be submitted to indexed medical journals and national and international meetings.The VITDAMI trial is an investigator initiated study, sponsored by the Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS-FJD). Funding has been obtained from Fondo de Investigaciones Sanitarias (PI14/01567; http://www.isciii.es/) and Spanish Society of Cardiology (http://secardiologia.es/). In addition, the study medication has been provided freely by the pharmaceutical Company FAES FARMA S.A. (Leioa, Vizcaya, Spain; http://faesfarma.com/). This company was the only funder who collaborated in study design (IG-H).S

InnovÁvila: Propuestas de innovación en la Escuela Universitaria de Educación y Turismo de Ávila para la excelencia docente

Memoria ID-038. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years